[SMC] Six-minute walk test to assess muscular fatigability and mobility in children with congenital myasthenic syndrome:

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Rev Assoc Med Bras (1992). 2026 May 1;72(1):e20250307. doi: 10.1590/1806-9282.20250307. eCollection 2026.

ABSTRACT

OBJECTIVE: The aims of this study were to determine whether the six-minute walk test predicts muscular fatigability in ambulant children with congenital myasthenic syndrome and to examine the relationship between the six-minute walk test and mobility tests.

METHODS: Eight children (four girls and four boys) with congenital myasthenic syndrome (mean age: 11.75±3.54 years) were included. Five children had COLQ variants. The distance of each minute for the six-minute walk test was determined to evaluate fatigability. The mobility tests included the 10-m walk/run test, rising from the floor, and climbing up and down four stairs.

RESULTS: The mean six-minute walk test distance was 463.38±132.59 m. There was no difference between the first and last minute, between the first and last two minutes, and between any of the minutes during the six-minute walk test (p>0.05). The mean times for performing the 10-m walk/run test, rising from the floor, and climbing up and down four stairs were 8.59±3.36, 6.38±4.49, 4.38±5.07, and 3.35±3.69 s, respectively. The strong correlations were determined between six-minute walk test and all the mobility tests, except for climbing down four stairs (p< 0.05, rs=-0.72 to -0.83).

CONCLUSION: The six-minute walk test did not provide sufficient evidence to predict muscular fatigability. However, this preliminary study suggested that the six-minute walk test may be used by clinicians and researchers to assess mobility in congenital myasthenic syndrome.

PMID:42090667 | DOI:10.1590/1806-9282.20250307


Source: https://pubmed.ncbi.nlm.nih.gov/4209066 ... t6+133c1fe