[Pubmed] Progressive Bulbar Weakness in an Older Male With Suspected Double-Seronegative Myasthenia Gravis Culminating i

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Cureus. 2026 May 27;18(5):e109753. doi: 10.7759/cureus.109753. eCollection 2026 May.

ABSTRACT

Myasthenia gravis is a rare autoimmune disorder affecting the neuromuscular junction, causing muscle weakness that worsens with use and improves with rest. While it is typically diagnosed through antibody tests or electrophysiological testing, a smaller subset of the population is seronegative or may have inconclusive electrophysiological results. In emergent presentations, seronegative myasthenia gravis is a challenge to diagnose clinically, making it imperative to identify it early to ensure proper management and treatment. Here, we present the case of an older male with a complex medical history and suspected seronegative myasthenia gravis who through the course of his admission experienced myasthenic crisis necessitating treatment with both intravenous immunoglobulin and plasmapheresis.

PMID:42367493 | PMC:PMC13307525 | DOI:10.7759/cureus.109753


Source: https://pubmed.ncbi.nlm.nih.gov/4236749 ... 2&v=2.20.0