Lu sur http://onlinelibrary.wiley.com/doi/10.1 ... avedsearch
Traduction disponible directement en cliquant en bas à droite de ce message sur notre forum
Rituximab in refractory myasthenia gravis: a prospective, open-label study with long-term follow-up
Dustin Anderson, Cecile Phan, Wendy S. Johnston andZaeem A. Siddiqi
Version of Record online: 25 MAY 2016 DOI: 10.1002/acn3.314
We examined the clinical effectiveness of rituximab in fourteen patients with refractory myasthenia gravis (MG).
Manual muscle testing (MMT) score was recorded at baseline and followed during the course of the study. Steroid dose, frequency of intravenous immunoglobulin (IVIG) infusions, and plasma exchange (PLEX) were also monitored throughout the duration of the study.
All patients responded dramatically to rituximab, as measured by a change in MMT score, prednisone dose, or the frequency of IVIG infusions or PLEX.
Rituximab appears safe and effective for the treatment of refractory MG. It should be considered as a therapeutic option in refractory patients.