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B-cell–activating factor is elevated in serum of patients with myasthenia gravis
Sa-Yoon Kang MD1,*, Chul-Hoo Kang MD1 andKeun-Hwa Lee PhD2
Version of Record online: 15 OCT 2016
Muscle Nerve, 2016
Myasthenia gravis (MG) is a B-cell–mediated autoimmune disease. B-cell–activating factor (BAFF) is a major factor in B-cell development and activation. In this study we investigated serum BAFF levels in MG patients.
We compared the serum BAFF levels of 20 MG patients with gender-matched healthy controls. We assayed serum concentrations of BAFF and anti-acetylcholine receptor antibody (AChR) titers.
Serum BAFF levels of MG patients with AChR antibodies were significantly higher than those of healthy controls. A significant positive correlation was observed between serum BAFF levels and anti-AChR antibody titers. BAFF values did not correlate with disease severity.
BAFF may play a major role in the pathogenesis of MG, and it may provide a potential target for therapy in patients with MG.