Résultats pathologiques chez des patients atteints de myasthénie grave avec hyperplasie thymique et thymome.

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Pboulanger
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Résultats pathologiques chez des patients atteints de myasthénie grave avec hyperplasie thymique et thymome.

Message par Pboulanger » 18 mars 2017 10:20

:hi:

Lu sur https://www.ncbi.nlm.nih.gov/pubmed/28299711


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Pathological Findings in Myasthenia Gravis Patients with Thymic Hyperplasia and Thymoma.
Chen P1, Wang YP2, Mou DL3, Li ZY4, Qu QM4, Wang HY5, Deng Y5, Li XF5, Wang T1, Xu XH6, Zhao G7.
Pathol Oncol Res. 2017 Mar 15. doi: 10.1007/s12253-017-0213-7.


Abstract

Thymectomy is routinely carried out in patients with myasthenia gravis (MG) and thymomas. However, there is still a dispute as to whether MG patients with thymic hyperplasia should undergo thymectomy.

We aimed to investigate the pathological findings in the thymus in patients with co-existing MG and thymic hyperplasia or thymomas treated with thymectomy, as well as effects of immunosuppression.

Thirty-three patients with MG were selected and grouped accordingly: patients with no thymic abnormalities, patients with thymic hyperplasia, and patients with thymomas.

All patients were treated with methylprednisolone alongside immunosuppression.

A separate cohort of 24 MG patients with thymic hyperplasia or thymomas and treated with thymectomy were selected.
As controls, 5 patients with thymomas or thymic carcinoma without MG were selected.
Expression of CD5, extracellular regulated protein kinases1/2 mitogen activated protein kinase (ERK1/2MAPKs) and CD95 ligand (FasL) in the thymus was examined.

Methylprednisolone and immunosuppressive therapy are highly effective in MG patients with normal thymus tissue and MG patients with thymic hyperplasia compared to MG patients with thymomas alone.

CD5 expression was highest in MG patients with thymic hyperplasia, correlating with expression of ERK1/2MAPKs. FasL expression was similar across all groups. Thymomas may be distinguished from thymic hyperplasia by expression of CD5 and ERK1/2MAPKs.

Thymectomy is the preferred treatment for MG patients with thymomas but may not be necessary in MG patients with thymic hyperplasia who are treated with immunosuppressive therapy.
Amicalement,
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