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Head-drop: A frequent feature of late-onset myasthenia gravis
Marvin Sih MD, Betty Soliven MD, Nicholas Mathenia MD, John Jacobsen MD, PhD andKourosh Rezania MD*
Version of Record online: 23 MAR 2017 DOI: 10.1002/mus.25526
Head-drop is often encountered in myasthenia gravis (MG) patients, but its frequency and clinical course have not been studied systematically.
In a retrospective study of a cohort of MG patients seen over a period of 11 years in a tertiary medical center, we assessed the clinical characteristics of patients who had head-drop.
Of 146 generalized MG patients, 15 had head-drop during the course of their disease. Head-drop patients had older age of onset than those who did not have head-drop (mean age of onset 59.1 vs. 42.3 years) and were predominantly men. Head-drop was present in 23% of patients > 60 versus 6% of those < 60 years, and it improved in 9 of 11 patients with treatment directed to generalized MG.
Head-drop is a common, treatment-responsive manifestation of late-onset MG.