[pubmed] Myasthenia Symptom Burden, Fatigue, and Sleep: Are They Related?

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J Clin Neuromuscul Dis. 2021 Mar 1;22(3):123-128. doi: 10.1097/CND.0000000000000321.

ABSTRACT

OBJECTIVE: Our aim is to explore the relationship between myasthenia gravis (MG)-related symptom burden, sleep quality, and fatigue in a diverse group of self-identified MG patients.

METHODS: Patients provided relevant myasthenia disease data and completed the MG QOL-15, Epworth sleepiness scale, Pittsburgh Sleep Quality Index, and fatigue severity score (FSS) online. MG activities of daily living scale (MG-ADL) was completed on a follow-up telephone interview.

RESULTS: One hundred ninety-six patients completed the online survey and 99 provided MG-ADL data. The mean age was 52 ± 15.34 years, 88 were acetylcholine receptor antibody positive, and 21 were muscle specific kinase positive. The mean MG-ADL was 6.81, indicating a moderate MG disease burden. Forty-seven (24%) reported high Epworth sleepiness scale scores, 152 (77%) reported high Pittsburgh Sleep Quality Index scores, and 162 (82%) reported high FSS scores. Correlation analysis correcting for body mass index and sleep apnea revealed a moderate positive correlation between MGQOL-15, MG-ADL, and FSS.

CONCLUSIONS: There is a moderate positive correlation between various MG-specific outcome measures and fatigue severity.

PMID:33595995 | DOI:10.1097/CND.0000000000000321


Source: https://pubmed.ncbi.nlm.nih.gov/3359599 ... 3&v=2.14.2