[Pubmed] Characterization of the nicotinic acetylcholine receptor antibodies after an unexpected increase of antibody ti

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Neuromuscul Disord. 2022 Aug 11:S0960-8966(22)00631-9. doi: 10.1016/j.nmd.2022.08.003. Online ahead of print.

ABSTRACT

Two thymoma-associated myasthenia gravis patients with chronic well-controlled disease but an unexpected increase in anti-nAChR autoantibodies titer are reported. The specificity of anti-nAChR autoantibodies directed against extracellular parts of the receptor was studied in order to investigate the discrepancy between clinical and immunological status. Analysis of the anti-nAChR autoantibodies recognizing the extracellular parts of the nAChR revealed that when the concentration of anti-nAChR autoantibodies titer increased both patients had non-anti-α1 autoantibodies. Since the clinical profile of both patients remained unchanged, the increase of non-anti-α1 autoantibodies did not affect the 2 patients' disease progression. Thus, immunotherapy modification due to an increase of anti-nAChR autoantibodies titer could be erroneous and potentially harmful.

PMID:36028368 | DOI:10.1016/j.nmd.2022.08.003


Source: https://pubmed.ncbi.nlm.nih.gov/3602836 ... 6&v=2.17.7