[Pubmed] Role of soluble forms of follicular helper T-cell membrane molecules in the pathogenesis of myasthenia gravis

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J Neuroimmunol. 2023 Jan 2;375:578014. doi: 10.1016/j.jneuroim.2022.578014. Online ahead of print.

ABSTRACT

This study examined the role of Tfh and Treg associated molecules also known as checkpoint molecules, their ligands, and IL-21 in myasthenia gravis (MG) pathogenesis. Serum levels of sPD-1, sPD-L1, sICOS, sICOSLG, sCTLA4, and IL-21 were measured in 39 patients with acetylcholine receptor (AChR) antibody-positive generalized MG and 27 controls. sPD-1 and IL-21 levels were higher in MG patients than in controls. Additionally, sPD-1 levels correlated positively with the levels of IL-21, sICOSLG, sCTLA4, and AChR antibody titers. sICOS are correlated with MGADL and AChR antibody titers. These Tfh associated molecules could be used as biomarkers of MG disease activity.

PMID:36621075 | DOI:10.1016/j.jneuroim.2022.578014


Source: https://pubmed.ncbi.nlm.nih.gov/3662107 ... t6+86293ac