[Pubmed] The impact of SARS-CoV-2 immunization on COVID-19 disease course in people with myasthenia gravis

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Muscle Nerve. 2023 Feb 22. doi: 10.1002/mus.27805. Online ahead of print.

ABSTRACT

INTRODUCTION/AIMS: There is limited knowledge regarding the impact of SARS-CoV-2 vaccines οn COVID-19 disease course in people with myasthenia gravis. In this study, we aimed to investigate whether SARS-CoV-2 vaccination influences hospitalization and mortality due to COVID-19 in this population.

METHODS: This is a retrospective analysis of administrative data extracted from the Greek nationwide database that holds the COVID-19 disease and vaccination registry, as well as all medical prescription records. The study period extended from the onset of the pandemic (February 2020) until the 10th of January 2022.

RESULTS: We identified 278 people with myasthenia gravis (mean age 58.1 ± 17.2, 47.5% males) who tested positive for SARS-CoV-2. Of those, 139 (50%) were not vaccinated at the time of infection. Multivariable binary logistic regression analysis showed that the probability of hospitalization increased with age (OR: 1.058; 95% CI, 1.036 - 1.080; p

Source: https://pubmed.ncbi.nlm.nih.gov/3681410 ... t6+86293ac