[Pubmed] Serum immunoglobulin G level reduction is a predictor of short-term improvement in patients with myasthenia gra

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Ther Apher Dial. 2023 Sep 20. doi: 10.1111/1744-9987.14065. Online ahead of print.

ABSTRACT

OBJECTIVES: The aim of the study was to investigate the serological factors in predicting symptom improvement in myasthenia gravis (MG) patients who underwent plasmapheresis (PP).

METHODS: The relationship between symptom improvement and change in immunoglobin G (IgG) and acetylcholine receptor antibody (AchR-Ab) levels in 21 MG patients after PP was analyzed.

RESULTS: Patients were divided into two groups: the favorable (n = 11) or unfavorable (n = 10) response groups around the median MG composite improvement rate (50 [29, 56]%) 2 weeks after a PP course. In all patients, the IgG reduction rate before and after PP was higher in the favorable than the unfavorable response group. In AChR-Ab-positive patients, IgG and AChR-Ab reduction rates were higher in the favorable than the unfavorable response group.

CONCLUSION: IgG reduction rate is a predictor of symptom improvement in MG patients who underwent PP.

PMID:37731293 | DOI:10.1111/1744-9987.14065


Source: https://pubmed.ncbi.nlm.nih.gov/3773129 ... t6+86293ac