[SMLE] Pre-existing Lambert-Eaton Myasthenic Syndrome and Scleroderma in a Patient with Neuroendocrine Carcinoma Undergo

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J Neuroimmunol. 2025 Jan 15;398:578485. doi: 10.1016/j.jneuroim.2024.578485. Epub 2024 Nov 12.

ABSTRACT

INTRODUCTION: Paraneoplastic neurological syndromes (PNS) can worsen with immune checkpoint inhibitor (ICI) cancer immunotherapy.

CASE REPORT: A 66-year-old female with paraneoplastic Lambert-Eaton Myasthenic Syndrome (LEMS), which led to the diagnosis of metastatic neuroendocrine carcinoma, was treated with intravenous immune globulin (IVIg) (with minimal response), chemotherapy, and radiation, resulting in neurological improvement. However, sclerodermatous changes developed after a year. Due to cancer progression, dual ICI therapy was initiated, and the patient remained stable for eight months until the progression of both LEMS and cancer, ultimately leading to death.

DISCUSSION: This case highlights the challenges of managing pre-existing PNS during ICI therapy, emphasizing the need for a multidisciplinary approach and the consideration of unusual clinical presentations in therapeutic decision-making.

PMID:39579734 | DOI:10.1016/j.jneuroim.2024.578485


Source: https://pubmed.ncbi.nlm.nih.gov/3957973 ... t9+e462414