[Pubmed] Cell models for studying myasthenia gravis

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Int Rev Neurobiol. 2025;182:121-143. doi: 10.1016/bs.irn.2025.04.026. Epub 2025 Jun 23.

ABSTRACT

Understanding the pathophysiology of Myasthenia Gravis (MG) and developing effective treatments requires using cell models that replicate key features of the disease, particularly those involved in the autoimmune response and neuromuscular dysfunction. This chapter reviews the various cell-based models used in MG research and those with potential for preclinical MG studies, including muscle cells and co-culture models to form neuromuscular junctions (NMJ). We discuss the strengths and limitations of these models, further outline methods for characterizing these, and provide an outlook on the future refinement and abilities of cell models for advancing MG research.

PMID:40675732 | DOI:10.1016/bs.irn.2025.04.026


Source: https://pubmed.ncbi.nlm.nih.gov/4067573 ... t9+e462414