[Pubmed] FcRn inhibitors for myasthenia gravis

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Cochrane Database Syst Rev. 2025 Aug 22;8:CD016097. doi: 10.1002/14651858.CD016097.

ABSTRACT

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of FcRn inhibitors for the maintenance treatment of myasthenia gravis in adult participants compared with control treatment (placebo, standard-of-care therapy, an alternative FcRn inhibitor, or an alternative immunomodulatory therapy). We will evaluate the efficacy of the treatment by the effect on disease severity and functional impairment, as assessed using a measurement tool validated for use in myasthenia gravis. Where possible, we will assess whether the effects of FcRn inhibitors differ according to different participant subgroups or different treatment regimens, or both. These data will be used to inform policymakers on the participant subgroups most likely to benefit from treatment and the most efficacious treatment regimen.

PMID:40843812 | DOI:10.1002/14651858.CD016097


Source: https://pubmed.ncbi.nlm.nih.gov/4084381 ... t9+e462414