[Pubmed] Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia

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Med Mycol Case Rep. 2025 Aug 20;49:100726. doi: 10.1016/j.mmcr.2025.100726. eCollection 2025 Sep.

ABSTRACT

Cryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indicating a disseminated cryptococcal infection. This case highlights the importance of maintaining a high index of suspicion for cryptococcal infection in immunosuppressed individuals, even without HIV/AIDS. Early detection is achieved by measuring serum cryptococcal antigen.

PMID:40893460 | PMC:PMC12397806 | DOI:10.1016/j.mmcr.2025.100726


Source: https://pubmed.ncbi.nlm.nih.gov/4089346 ... t9+e462414