[Pubmed] Surgical management of suspected paraneoplastic myasthenia gravis in rectal cancer during neoadjuvant immunothe

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Front Oncol. 2025 Sep 2;15:1503362. doi: 10.3389/fonc.2025.1503362. eCollection 2025.

ABSTRACT

Colorectal cancer is among the most common malignancies of the gastrointestinal tract. Immune checkpoint inhibitors (ICIs) have become a key component in the treatment of locally advanced rectal cancer (LARC), offering promising therapeutic outcomes. However, ICIs can occasionally cause significant adverse effects. Herein, we report a case of rectal cancer with suspected paraneoplastic myasthenia gravis (pMG) induced by immune checkpoint inhibitors (ICIs). Unfortunately, the patient lacked anti-acetylcholine receptor (AChR)/muscle-specific kinase (MuSK) antibody testing and muscle biopsy, which precluded a definitive diagnosis of pMG. Remarkably, following surgical resection, the patient not only achieved complete tumor eradication but also experienced full remission of myasthenia gravis (MG).

PMID:40963855 | PMC:PMC12436094 | DOI:10.3389/fonc.2025.1503362


Source: https://pubmed.ncbi.nlm.nih.gov/4096385 ... t9+e462414