[Pubmed] Prevalence and outcomes of co-occurring psychiatric and neurological disorders: An atlas based on umbrella revi

[RSS-Bot]

Eur Neuropsychopharmacol. 2026 Mar 26;109:112820. doi: 10.1016/j.euroneuro.2026.112820. Online ahead of print.

ABSTRACT

Psychiatric and neurological disorders often co-occur, complicating their assessment, management, and outcomes. No umbrella review (UR) has summarized the meta-analytic evidence on the co-occurrence of psychiatric and neurological disorders and assessed its credibility. Meta-analytic systematic reviews of observational studies documenting the prevalence and outcomes associated with the co-occurrence of neurological and psychiatric disorders, indexed from inception through August 25, 2025, and meeting established diagnostic criteria, were included. Meta-analytic prevalence and association estimates were recalculated and graded based on quantitative criteria. The AMSTAR-2 assessed the quality of the meta-analyses, while several subgroup analyses and meta-regressions aimed to explain the heterogeneity. We included 81 meta-analyses (N=42,464,788, k=2,273), yielding 166 meta-analytic estimates. Based on pre-existing meta-analytic evidence, among 90 prevalence estimates, 45 (50%) met moderate/strong credibility criteria. Strong credibility emerged in bipolar disorder for comorbid migraine (34.8%,95%CI=25.54-44.69) and chronic pain (28.9%,95%CI=16.4-43.4), in epilepsy for ADHD (22.3%,95%CI=20.3-24.4), depression (23.1%,95%CI=20.6-28.3), autism (11.1%,95%CI=9.8-12.1), and PTSD (7.7%,95%CI=5.2-11.2), in myasthenia gravis for anxiety (33%,95%CI=25.0-42.0 children), in multiple sclerosis for anxiety (36%,95%CI=30.0-42.0) and depression (27.01%,95%CI=22.80-31.68), in neuropathic chronic pain for depression (37.5%,95%CI=28.7-47.1) and anxiety (33.8%,95%CI=28.5-39.6), in neuromyelitis optica for depression (40%,95%CI=32.0-49.0), in stroke for anxiety (29.3%,95%CI=24.8-33.8) and depression (31%,95%CI=24.0-38.0 children), in dementia for depression (25.01%,95%CI=22.1-28.4). Several additional disorders were comorbid in >5%with lower credibility. No outcomes reached strong credibility criteria. The present study provides an atlas of neurological and psychiatric multimorbidity across varying levels of credibility, reinforcing the need for an integrated, multidisciplinary approach to patient care and for more research on actionable risk/protective factors and outcomes.

PMID:41895003 | DOI:10.1016/j.euroneuro.2026.112820


Source: https://pubmed.ncbi.nlm.nih.gov/4189500 ... t6+133c1fe