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Validation of the besta neurological institute rating scale for myasthenia gravis
Carlo Antozzi MD1,*, Greta Brenna MSc1, Fulvio Baggi PhD1, Giorgia Camera MD1, Lorenzo Maggi MD1, Cristiana Rezzani PhD2, Cristina Montomoli PhD2 andRenato Mantegazza MD1
Article first published online: 10 OCT 2015
We validated the scale for myasthenia gravis (MG) developed at the Neurological Institute Foundation of Milan (INCB-MG scale).
A total of 174 patients were evaluated with the INCB-MG and compared with the MG Composite (MGC) as the gold standard. Dimensionality, reliability, and validity of the INCB-MG scale were studied by principal component factor analysis, Cronbach alpha, and Pearson correlation coefficients; interobserver reliability was calculated by the weighted Cohen K coefficient.
Generalized and bulbar INCB-MG subscales were unidimensional with excellent consistency; the INCB-MG and MGC scales were strongly correlated. Fatigability assessment was correlated with the INCB-MG generalized, bulbar, and respiratory subscales.
The INCB-MG scale is a reliable tool to assess MG and is strongly correlated with the MGC. The INCB-MG scale is a valid tool for every day practice and should be further investigated for its application in clinical trials.
Muscle Nerve, 2015